Sustained viral response in a hepatitis C virus-infected chimpanzee via a combination of direct-acting antiviral agents.
نویسندگان
چکیده
Efforts to develop novel, interferon-sparing therapies for treatment of chronic hepatitis C (HCV) infection are contingent on the ability of combination therapies consisting of direct antiviral inhibitors to achieve a sustained virologic response. This work demonstrates a proof of concept that coadministration of the nucleoside analogue MK-0608 with the protease inhibitor MK-7009, both of which produced robust viral load declines as monotherapy, to an HCV-infected chimpanzee can achieve a cure of infection.
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ورودعنوان ژورنال:
- Antimicrobial agents and chemotherapy
دوره 55 2 شماره
صفحات -
تاریخ انتشار 2011